| Spherisator S |
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The Spherisator S is the ideal encapsulation unti for trials and feasibility studies powered by the patented BRACE technology.
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Spherisator S
Like every other BRACE-Spherisator, the new Spherisator S consists of an external control box and a microsphere dripping device. This is made of GMP/GLP-applicable stainless steel (1.4571/AISI316Ti) with an electropolished surface finish. The control box for your Spherisator S is available as a Laptop with 15” screen size or as a desktop PC with a separate 17” TFT display. The control software is part of the scope of delivery and is pre-installed on your control box. It is also possible to purchase just the control software in order to install it on your own Laptop or desktop PC. You can configure your “individual” Spherisator S to your specific requirements by simply choosing separate modules out of our wide range of different modules. The Spherisator S can be operated using power supplies delivering 230V / 50 Hz (e.g. Western Europe) as well as using power supplies delivering 115 V / 60 Hz (e.g. USA and Canada) or 100 V / 60 Hz (e.g. Japan). An external transformer, which is part of the delivery scope, transforms these lower power currencies to 230 V. In general, the Spherisator S is designed for the production of microcapsules. Nevertheless, any Spherisator S can be used to produce microspheres as well. Microspheres are solid spheres consisting of a matrix, e.g. alginate, wherein another substance is embedded. Microcapsules, on the other hand, consist of a liquid or solidified core which is surrounded by a solid shell, e.g. alginate or gelatin.
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Nozzles and Nozzle Heads
By the selection of the nozzle diameter you can vary the diameter of the microspheres and microcapsules which are to be produced. As an order of magnitude you can assume that the diameter of the produced microspheres (as dripped) is some 1,89X of the nozzle diameter. Nevertheless, the properties of the dripping liquid(s) have to be taken into consideration when selecting the appropriate nozzle diameter(s).
We are very pleased to help you individually when selecting the ideal nozzles for your process – please feel free to contact BRACE.
You can select your nozzles from the following standard nozzles sizes: In the area from 50 to 500 µm in steps of 50 µm, in the area from 500 to 1000 µm in steps of 100 µm and in the area from 1000 µm to 6000 µm in steps of 200 µm. If you need a different diameter which is not in this list, please contact us for an individual quote.
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Feed Vessels
Our feed vessels with a usable volume between 0,25 L and 5 L fit precisely into the designated feed vessel holders of the Spherisator S. They are delivered with fittings, top cover, and clamping ring. A feed tubing made of PTFE/PVDF, in which the feed liquid is transported from the feed vessel to the dripping unit, is also scope of delivery. The standard material of our feed vessels is glass. As an alternative you can order feed vessels made of stainless steel. For the stainless steel DIN 1.4404/AISI316L we offer also the surface finish “electropolished”. | |
Reaction Vessel
When using a reaction vessel you can collect the produced microgranules and – when using an appropriate solidification system – solidify them chemically. For example: If alginate is used as shell or matrix material, solidification – and therefore the stabilisation of the perfectly round shape – of the microgranules can be achieved by dripcasting the granules into an aqueous solution of CaCl2.
Our reaction vessels are available with volumes ranging from 1 L to 5 L. As vessel materials you can choose between glass, PMMA, or stainless steel.
Furthermore, you can choose between different types of vessels: A vessel with an integrated overflow can be used to keep the level of the reaction fluid steady. Therefore, the distance between nozzle and reaction fluid is being kept steady as well which results in longer production times without the need to change the reaction vessel. If the collecting solution is stirred with a stirrer, the produced microgranules are transferred more rapidly from the surface – the dripcasting area – to farther or lower parts of the reaction vessel. This reduces the risk of deformation and coagulation which can occur through direct contact of two or more not yet solidified particles. A manual or electrical elevation control allows to adjust the distance among nozzle and collecting solution to an optimal value for your individual dripcasting system.
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Please note also the  complete catalogue for the Spherisator S and M series. |
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Updated Tuesday, December 30, 2008 |
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